Table 4.
Known high TdP risk drugs and CYP strong inhibitors interactions.
| CYP Metabolizer | Drug with a Known TdP Risk | Type X Interactions When Combined with (High Risk of QT Prolongation) |
|---|---|---|
| CYP3A4 | Amiodarone | Voriconazol |
| Indinavir | ||
| Ritonavir | ||
| Saquinavir | ||
| Clarithromycin | ||
| Disopyramide | Itraconazol | |
| Clarithromycin | ||
| Ketoconazol (systemic) | ||
| Saquinavir | ||
| Telithromycin | ||
| Dofetilide | Clarithromycin | |
| Itraconazole | ||
| Ketoconazole | ||
| Dronedarone | Clarithromycin | |
| Ceritinib | ||
| Indinavir | ||
| Itraconazole | ||
| Nefazodone | ||
| Ritonavir | ||
| Saquinavir | ||
| Telithromycin | ||
| Voriconazole | ||
| Ibutilide | Clarithromycin | |
| Quinidine | Clarithromycin | |
| Itraconazol | ||
| Ketoconazol | ||
| Ritonavir | ||
| Saquinavir | ||
| Voriconazole | ||
| Azithromycin | Certinib | |
| Clarithromycin | ||
| Saquinavir | ||
| Voriconazole | ||
| Clarithromycin | Saquinavir | |
| Erythromycin | Saquinavir | |
| Cloroquine | Ceritinib | |
| Clarithromycin | ||
| Saquinavir | ||
| Voriconazole | ||
| Chlorpromazine | Certinib Saquinavir |
|
| Voriconazol | ||
| Clarithromycin | ||
| Haloperidol | Saquinavir | |
| Levomepromazine | Ritonavir Saquinavir |
|
| Escitalopram | - | |
| Ondansetron | - | |
| Cisapride | Ceritinib | |
| Clarithromycin | ||
| Indinavir | ||
| Itraconazole | ||
| Ketoconazole | ||
| Nefazodone | ||
| 2D6 | Flecainide | |
| Ibutilide | Quinidine | |
| Procainamide | Quinidine | |
| Chloroquine | - | |
| Hydroxychloroquine | - | |
| Chlorpromazine | - | |
| Haloperidol | - | |
| 2C19 | Citalopram | - |
| Escitalopram | - | |
| Chlorpromazine | - |
The drugs metabolized by a given CYP were crossed with the drugs known inhibit the respective CYP (See Supplementary Table S1) taken from [91]. Known TdP risk drugs were taken from CredibleMeds® list of known risk of TdP drugs [24]. Drug interactions were analyzed for the potential drug interactions using Lexi-Interact™ Online available on the website www.uptodate.com (accessed on 10 June 2021) [89].