Table 5.
Drug | Increased Risk in the Setting of | Use Causes Hypokalemia and/or Hypomagnesemia |
Reduces Elimination of a QT/TdP Drug |
Use in cLQTS | ||||
---|---|---|---|---|---|---|---|---|
Bradycardia | Hypokalemia/ Hypomagnesemia |
Excesive Dose | Use with Concomitant QT/TdP Drug | Impaired Drug Elimination |
||||
Abiraterone | X | |||||||
Amantadine | X | X | X | X | ||||
Amisulpride | X | X | X | |||||
Amitriptyline | X | X | X | X | X | |||
Amphotericin B | X | X | ||||||
Amsacrine | X | |||||||
Atazanavir | X | |||||||
Bendroflumethiazide | X | X | ||||||
Chloral hydrate | X | |||||||
Cimetidine | X | X | X | X | ||||
Clomipramine | X | X | X | |||||
Diphenhydramine | X | |||||||
Doxepin | X | X | X | X | ||||
Eperisone | X | |||||||
Esomeprazole | X | X | ||||||
Famotidine | X | X | X | X | ||||
Fluoxetine | X | X | X | X | X | |||
Fluvoxamine | X | X | X | X | ||||
Furosemide | X | X | ||||||
Galantamine | X | X | X | X | ||||
Garenoxacin | X | X | ||||||
Hydrochlorothiazide | X | |||||||
Hydroxyzine | X | X | X | X | ||||
Indapamide | X | X | ||||||
Itraconazole | X | X | ||||||
Ivabradine | X | X | X | X | ||||
Ketoconazole | X | X | X | |||||
Lansoprazol | X | X | ||||||
Loperamide | X | X | ||||||
Metoclopramide | X | X | X | X | ||||
Metolazone | X | X | X | X | ||||
Metronidazole | X | X | ||||||
Nelfinavir | X | X | X | |||||
Olanzapine | X | X | ||||||
Omeprazole | X | X | ||||||
Pantoprazole | X | X | ||||||
Paroxetine | X | |||||||
Piperacilin/tazobactam | X | X | X | X | ||||
Posaconazole | X | X | X | X | X | |||
Propafenone | X | X | X | |||||
Quetiapine | X | X | X | X | X | |||
Quinine sulfate | X | X | X | |||||
Ranolazine | X | X | X | X | ||||
Risperidone | X | X | X | X | ||||
Sertraline | X | X | X | X | ||||
Solifenacin | X | X | X | |||||
Telaprevir | X | X | ||||||
Torsemide | X | X | ||||||
Trazodone | X | X | X | X | ||||
Voriconazole | X | X | X | |||||
Ziprasidone | X | X | X | X |
Adapted from: CredibleMeds® list of drugs with a conditional risk for TdP [24].