Table 3.

Pharmacokinetic parameters of erinacine A in rat plasma after oral administration of H. erinaceus mycelia extract at 2.381 g/kg body weight (equivalent to 50 mg/kg BW of erinacine A) and intravenous administration of erinacine A at 5 mg/kg.

	P.O.	I.V.
	(50 mg/kg)	(5 mg/kg)
Tmax (min)	360.00 ± 131.45	−
Cmax (μg/mL)	1.40 ± 1.14	4.53 ± 3.42
T1/2 (min)	491.22 ± 111.70	4.37 ± 4.55
AUC (min × μg/mL)	457.26 ± 330.50	187.50 ± 105.29
Absolute Bioavailability (%)	24.39

P.O.: oral administration; iv: intravenous administration. Data expressed as mean ± SD (n = 6). T_max: the time taken to reach the maximum concentration. C_max: maximum plasma concentration. T_1/2: half-life. AUC: area under the plasma concentration-time curve. Absolute bioavailability (%) = [(AUCpo × Doseiv)/(AUCiv × Dosepo)] × 100%.