Figure 1.

hiPSC-derived brain models in drug discovery. Diagram illustrating the use of hiPSCs to generate various brain cells (neurons, astrocytes, microglia) and 3D cerebral organoids, which can be used to model different neurological disorders. Myelin-forming oligodendrocytes can also be modeled with hiPSC differentiation protocols but are not shown here. These hiPSCs can be used for drug discovery using various methods, e.g., high-throughput screening, CRISPR screening, and Connectivity Map score for transcriptome correction.