Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 26;22(15):7952. doi: 10.3390/ijms22157952

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Adenosine A₃ receptors and peripheral mechanisms for pain control. (A) A₃ receptors (A₃Rs) expressed on rat DRG neurons decrease action potential (AP) firing by blocking neuronal excitability. The same receptor subtype also inhibits N-type voltage-gated calcium channels (Ca_V), thus reducing glutamate (Glu) release at the synapse [67]. (B) In a mouse model of CCI, A₃Rs expressed on CD4⁺ T cells, but not on mouse DRG neurons in this rodent species, promote interleukin-10 (IL-10) release, which, by activating IL-10 receptors (IL-10R) on DRG neurons, reduces neuronal excitability [73].