Table 4.
List of anti-MRSA activity of bioactive compounds, producers and their chemical classes isolated from Actinobacteria.
| Antibiotic | Producer | Chemical Class | Reference |
|---|---|---|---|
| Angumicynones A (1); Angumicynones B (2); Angucyclinones analogues compounds 3–8 |
Streptomyces sp. MC004 | Angucyclic quinones | [94] |
| Watasemycin A (3) | Thiazostatins |
||
| Pulicatin G (4) and aerugine (5) |
Benzyl thiazole and thiazoline | ||
| Polyketide [2-hydroxy-5-((6-hydroxy-4-oxo-4H-pyran-2-yl) methyl)-2-propylchroman-4-one] |
Streptomyces sundarbansensis WR1L1S8 |
N/A | [95] |
| Azalomycin F5a (1) and its four derivative compounds: |
Streptomyces hygroscopicus var. azalomyceticus |
Polyhydroxy macrolide | [96] |
| Gargantulide A | Streptomyces sp. A42983 | Macrolactone | [97] |
| New Ikarugamycins: Compound 1: Isoikarugamycin; Compound 2: 28-N-methylikarugamycin; Compound 3: 30-oxo-28-N-methyl-ikarugamycin; Compound 4: Ikarugamycin; Compound 5: MKN-003B; Compound 6: 1 H-indole-3-carboxaldehyde; Compound 7: Phenylethanoic acid |
Streptomyces zhaozhouensis CA-185989 |
Compounds 1- 4: Pentacyclic tetramic acid macrolactams; Compound 5: Butenolide; Compound 6: Indole; Compound 7: Acetic acid |
[98] |
| Pyrrole-Like Structure | Streptomyces sp. MN41 | pyrrole | [99] |
| actinomycins V, X2 and D. |
Streptomyces antibioticus NBRC 12838T |
Actinomycins | [100] |
| Abyssomicin C | Actinobacteria | polyketide | [93] |
| laidlomycin | Streptomyces sp. CS684 | affecting the metabolism | [89] |
| Neocitreamicins I and II | Nocardia | [93] | |
| Etamycin | Actinomycetes strains CNS-575 | cyclic peptide | [101] |
| Dichloromethane | Actinobacteria (I-400A, B1-T61, M10-77) | N/A | [93] |
| 2, 4-dichloro-5-sulfamoyl benzoic acid (DSBA) | Streptomyces sp. VITBRK2 | N/A | [93] |
Abbreviation: S. = (Streptomyces), N/A; not applicable.