Table 2.
Viruses and their effects on mitochondrial dynamics.
S.No. | Author & Year | Virus | Work & Object |
---|---|---|---|
1 | Horner and Gale, 2013 [98] | Hepatitis C virus (HCV) | HCV cleaves the MAVS protein and suppresses the host’s antiviral response. |
2 | Datan et al., 2016 [99], Liang et al., 2016 [100] | Dengue and Zika virus | With the help of autophagy, the Dengue and Zika viruses improve their replication and the induction of autophagy by pharmacological agents (e.g., rapamycin) increasing viral dissemination. |
3 | Joubert et al., 2012 [101] | Chikungunya virus | Autophagy limits virus-induced cell death and in vivo mortality in Chikungunya virus. |
4 | Datan et al., 2016 [99]; Lee et al., 2008 [102]; McLean et al., 2011 [103] | Dengue virus | Autophagy inhibits apoptosis to enhance virus replication in the Dengue virus. |
5 | Zhu et al., 2016 [104] | Transmissible gastroenteritis virus (TGEV) | TGEV-induced complete mitophagy by stimulating DJ1-1 protein deglycase which increases cell survival and infection by eliminating virus-induced ROS. |
6 | Meng et al., 2014 [105] | Newcastle disease virus (NDV) | Delayed administration of 3 methyl adenine (3-MA) induced more efficient oncolysis in NSCLCs. |
7 | Barbier et al., 2017 [106] | Dengue virus | In the Dengue virus, mitochondrial fission is blocked because the Dengue virus’ NS4B or NS3 protein promotes mitochondrial fusion by downregulating Drp1. |
8 | Yu et al., 2015 [107] | Dengue virus | In the case of the Dengue virus, mitochondrial fusion is suppressed by NS2B3 protease which cleaves MFNs. |
9 | Zamarin et al., 2005 [108] | Influenza A virus | PB1-F2 have an essential role in the pathogenicity of the viral infection of influenza virus A, via modulation of the host’s mitochondrial dynamics. |
10 | Kim et al., 2013b [109] | Hepatitis C virus (HCV) | HCV stimulates the expression of parkin, PINK1 and induced mitophagy by impairing oxidative phosphorylation. The resulting HCV infection affects mitochondrial dynamics. |
11 | Gou et al., 2017 [110] | Classical swine fever virus (CSFV) | CSFV expresses MFN2 and stimulates parkin and PINK1 expression, resulting in enhanced mitochondrial fission and mitophagy. |
12 | Ding et al., 2017 [111] | Human parainfluenza virus type 3 (HPIV3) | In HPIV3 infection, a viral protein regulates mitophagy independently of parkin/PINK1. |
13 | Xia et al., 2014b [112] | Measles virus | During the measles viral infection, virus-induced antiviral immune response is enhanced by the knockdown of autophagy-related genes (eg, ATG7, BECN1, SQSTM1, and RAB7). |