|
Autophagy |
UPR stress |
MPTP |
NLRP3 Inflammasome |
Activator |
Modulator |
Inhibitor |
Suppressor |
Modulator |
Modulator |
Inhibitor |
Immunosuppressant |
Rapamycin, Tacrolimus, Everolimus [152] |
|
Cyclosporin A [153,154] |
|
Anticancer |
Rapamycin, Tersirolimus, Everolimus [152], Gefitinib [155], Temozolomide [155] |
|
Bortezomib, Celecoxib [155] |
Sunitinib [156] |
|
Thalidomide [157] |
Antidiabetic |
Metformin [152] |
|
Pioglitazone [156], Exenatide, Vildagliptin [158], Berberine [159] |
Liraglutide [159] |
|
Glyburide [157,160] |
Dietary supplement |
Trehalose, Resveratro l [152] |
|
Curcumin [156] |
Quercetin [161] |
|
Antipsychotic |
Lithium [152], Fluspirilene, Trifluperazine, Pimozide [162], Bromperidol, Chlorpromazine [163,164], Sertindole, Olanzapine, Fluphenazine, Methotrimeprazine [165], Prochlorperazine [164] |
Clozapine [165] |
|
Haloperidol [166,167,168], Etifoxine [169,170] |
|
Antiepileptic |
Carbamazepine, Sodium valproate [152] |
|
Antihypertensive |
Verapamil, Nimodipine, Nitrendipine [152], Nicardipine, Amidarone [162], Rilmenidine, Clonidine [171], Minoxidil [163] |
|
Isoproterenol [156], Valsartan, Lowsartan, Olmesartan, Telmisartan [158], Guanabenz [172], Bisoprolol, Propranolol, Metoprolol [159] |
|
Ifenprodil [166,167,168], Diazoxide, Nicorandil, Tadalafil, Perhaxiline, Carvedilol [153,154] |
|
Antidiarrheal |
Loperamide [162] |
|
Ca+ regulator |
Calcifediol [171] |
|
Anti-infective |
Nitazoxanide [171] |
Antidepressant |
Nortriptyline [171] |
|
Clomipramine [163] |
Trazodone [173] |
|
AnticholesteremiC agent |
Simvastatin [170] |
|
Atorvastatin [159] |
|
Antiemetic |
Chlorpromazine [163,164], Prochlorperazine [164] |
|
Haloperidol [166,167,168] |
Thalidomide [157] |
Minercorticoid replacement agent |
Fludraocortisone [163,164] |
|
Antitussive |
Noscapine [163,164] |
|
Carbetapentane, Dextromethorphan [166,167,168] |
|
Anti-allergic |
Clemastine [163] |
|
Chelating agent |
Defeiprone [174] |
Antihelmintic |
Niclosamide [175] |
|
Quimacrine [176,177] |
|
Skeletal muscle relaxant |
|
Baclofen [178] |
|
Gastrointestinal |
|
Pantoprazole [155] |
|
Macrolide antibiotic |
Azithromycin [163] |
Ocular drug |
Verteporfin [163] |
Antiprotozoal drug |
Quimacrine [176,177], Chloroquine, Hydroxychloroquine [171] |
Urea cycle disorder agent |
|
Thenylbutyrate [155,156] |
|
Hypolipidemic agent |
Pravastatin [156], Fenofibrate [158] |
Anti-Alzheimer’s |
|
Donepeziol [166,167,168] |
|
Anti-Parkinsonian |
Pramipexole [179] |
Neuroprotective agent; anti-ALS drug |
Edaravone [153,180] |
Anti-arthritic |
|
Anakinra [157] |
Anti-inflammatory agent |
|
Celecoxib [155] |
|
Anakinra [157], Tranilast [157,181] |
Anti-insomia agent |
|
Melatonin [182] |
|