Table 2.

Proportional hazard risk model evaluating impact of lower in-trial than baseline RHR.

Parameter	Hazard Ratio	95% Confidence Interval	p-Value
Age (years)	1.05	1.04–1.06	<0.001
Female sex	0.69	0.57–0.84	<0.001
Allocation to intensive treatment arm	0.74	0.63–0.87	<0.001
Current smoking status	1.92	1.51–2.45	<0.001
History of cardiovascular disease	2.17	1.81–2.599	<0.001
History of chronic kidney disease	1.46	1.22–1.74	<0.001
Baseline SBP (mm Hg)	1.01	1.00–1.01	0.024
Baseline RHR (b.p.m.)	1.01	1.00–1.01	0.190
Total serum cholesterol (mg/dl)	1.00	0.99–1.00	0.027
Lower in-trial RHR than at baseline	0.80	0.66–0.98	0.020

SBP, systolic blood pressure; RHR, resting heart rate.