Table 2.
Proportional hazard risk model evaluating impact of lower in-trial than baseline RHR.
| Parameter | Hazard Ratio | 95% Confidence Interval | p-Value |
|---|---|---|---|
| Age (years) | 1.05 | 1.04–1.06 | <0.001 |
| Female sex | 0.69 | 0.57–0.84 | <0.001 |
| Allocation to intensive treatment arm | 0.74 | 0.63–0.87 | <0.001 |
| Current smoking status | 1.92 | 1.51–2.45 | <0.001 |
| History of cardiovascular disease | 2.17 | 1.81–2.599 | <0.001 |
| History of chronic kidney disease | 1.46 | 1.22–1.74 | <0.001 |
| Baseline SBP (mm Hg) | 1.01 | 1.00–1.01 | 0.024 |
| Baseline RHR (b.p.m.) | 1.01 | 1.00–1.01 | 0.190 |
| Total serum cholesterol (mg/dl) | 1.00 | 0.99–1.00 | 0.027 |
| Lower in-trial RHR than at baseline | 0.80 | 0.66–0.98 | 0.020 |
SBP, systolic blood pressure; RHR, resting heart rate.