Table 1.
Characteristics of the studies on the effect of maternal gene variations on developmental arrest.
| Study ID | GENE | Variations | Study Origin | Sample Size | |
|---|---|---|---|---|---|
| Tian | ZAR1 | rs117545505 and rs17609740 | China | 47 women with cleavage failure | Controls: 93 women undergoing IVF/ICSI and 188 women with natural conception |
| Sha | TUBB8 | NP | China | 66 women | |
| Chen | TUBB8 | 28 variants | China | 30 families | |
| Yuan | TUBB8 | c.322G>A | China | 1 woman and 178 controls | |
| Wang | REC114 | c.546 + 5G>A | China | 2 families | |
| Zheng | PADI6 | c.1521dupC, c.A1117C and c.C1708T | China | 2 women | |
| Quian | PADI6 | c.1793A>G and c.2045 G>A, | China | 1 family | |
| Wang 2018 | PADI6 | c.866C>T, c.1895C>T and c.1124dupT | China | 2 families and 80 infertile controls | |
| Xu | PADI6 | c.2009_2010del c.633T>A c.1618G>A c.970C>T | China | 2 out of 36 women | |
| Mu | NLRP2 | c.1961C>A, c.773T>C, c.2254C>T, c.525G>C, c.2544A>T, c.662C>T, c.1847A>T, c.1469C>T | China | 5 families | |
| Mu | NLRP5 | c.292C>T, c.2081C>T, c.866G>A, c.3320C>T | China | 2 families | |
| Wu | PATL2 | p.V260M, p.Q300*, p.T425P, p.D293Y p.N239Tfs*9 p.R75Vfs*21 | China | 5 families | |
| Wang 2018 | TLE6 | c.1133delC | China, however the family was from Ukraine | 1 family and 80 infertile controls | |
| Wang 2018 | KHDC3L | c.44delA | China | 1 family and 80 infertile controls | |