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Illustration of hypothetical inactivation of mechanosensitive PP2A during cell shrinkage. PP2A can be compressed by both HPout and FsmACSK and thus inactivated. Inactivation of PP2A would increase phosphorylation of NKCC1 by PKs that would activate NKCC1 and lead to RVI. In addition, phosphorylation of KCC by PKs would inactivate it.
