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. 2021 Jul 31;22(15):8281. doi: 10.3390/ijms22158281

Figure 1.

Figure 1

The genotoxic effects of cocultivation of GCT cell lines with PBMCs from healthy donors. The comet assay was used to determine levels of DNA damage in PBMCs after 96 and 120 h of cocultivation with the yolk sac tumor cell line NOY-1, embryonal carcinoma cell line NTERA-2, seminoma cell line TCam-2, and their CDDP-resistant (CisR) variants. Data represent the means ± SEM of three independent experiments (raw data are presented in table below Figure 1). p values (* p  <  0.05 and ** p  <  0.01) indicate statistically significant differences in DNA damage levels between PBMCs cocultivated with CDDP-sensitive GCT cell lines and those cocultivated with their corresponding resistant variants (ANOVA test). The table belonging to the Figure 1 summarizes raw data to the evaluation of genotoxic effects of co-cultivation of germ cell tumor cell lines and their CDDP-resistant variants with PBMCs from healthy donor.