Table 3.
Association between the endogenous DNA damage level and percentages of different leukocyte subpopulations in GCT patients. Univariate and multivariate logistic regression analysis was used for statistical evaluation of the obtained data.
| Variable | % of Individual Leukocytes Subpopulation | |||||
|---|---|---|---|---|---|---|
| N | Mean | SEM | Median | p Value b | p Value c | |
| Neutrophils percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 55 | 61.7 | 1.9 | 61.1 | 0.462 | |
| endogenous DNA damage level > 6.34 | 19 | 63.9 | 3.2 | 63.4 | ||
| Lymphocytes percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 54 | 27.5 | 1.7 | 26.6 | 0.232 | |
| endogenous DNA damage level > 6.34 | 19 | 23.6 | 2.9 | 20.9 | ||
| Monocytes percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 55 | 9.3 | 0.4 | 9.2 | 0.347 | |
| endogenous DNA damage level > 6.34 | 19 | 10.2 | 0.7 | 9.6 | ||
| Eosinophils percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 55 | 2.5 | 0.4 | 2.7 | 0.334 | |
| endogenous DNA damage level > 6.34 | 19 | 3.0 | 0.6 | 2.7 | ||
| Basophils percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 55 | 0.6 | 0.04 | 0.3 | 0.064 | |
| endogenous DNA damage level > 6.34 | 19 | 0.8 | 0.07 | 0.4 | ||
| B cells percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 55 | 12.6 | 0.7 | 11.8 | 0.00058 | 0.60005 |
| endogenous DNA damage level > 6.34 | 19 | 8.3 | 1.2 | 8.0 | ||
| T cells percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 55 | 72.9 | 1.2 | 73.6 | 0.848 | |
| endogenous DNA damage level > 6.34 | 19 | 71.9 | 2.1 | 74.4 | ||
| T helper cells percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 54 | 45.4 | 1.2 | 45.8 | 0.530 | |
| endogenous DNA damage level > 6.34 | 19 | 43.3 | 2.0 | 43.6 | ||
| T cytotoxic cells percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 55 | 25.6 | 1.0 | 24.5 | 0.669 | |
| endogenous DNA damage level > 6.34 | 19 | 26.2 | 1.6 | 26.9 | ||
| NKT cells percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 53 | 1.7 | 0.4 | 2.4 | 0.057 | |
| endogenous DNA damage level > 6.34 | 19 | 3.1 | 0.6 | 3.3 | ||
| CD4+ NKT cells percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 24 | 0.2 | 0.1 | 0.3 | 0.155 | |
| endogenous DNA damage level > 6.34 | 11 | 0.7 | 0.2 | 0.9 | ||
| CD8+ NKT cells percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 25 | 1.7 | 0.4 | 1.5 | 0.243 | |
| endogenous DNA damage level > 6.34 | 11 | 2.7 | 0.5 | 2.4 | ||
| NK cells percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 55 | 11.3 | 1.1 | 9.6 | 0.008 | 0.00063 |
| endogenous DNA damage level > 6.34 | 19 | 17.3 | 1.9 | 13.6 | ||
| Tregs percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 55 | 3.8 | 0.2 | 3.8 | 0.03937 | 0.01588 |
| endogenous DNA damage level > 6.34 | 19 | 4.5 | 0.3 | 4.4 | ||
| Classical monocytes percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 41 | 87.6 | 1.1 | 87.9 | 0.256 | |
| endogenous DNA damage level > 6.34 | 17 | 85.7 | 1.7 | 86.5 | ||
| Intermediate monocytes percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 24 | 4.7 | 0.5 | 4.3 | 0.546 | |
| endogenous DNA damage level > 6.34 | 11 | 5.2 | 0.8 | 3.7 | ||
| Nonclassical monocytes percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 40 | 4.5 | 0.5 | 4.8 | 0.714 | |
| endogenous DNA damage level > 6.34 | 17 | 5.9 | 0.7 | 4.6 | ||
| Polymorphonuclear leukocytes (PNMs) percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 36 | 1.0 | 0.5 | 0.3 | 0.0753 | |
| endogenous DNA damage level > 6.34 | 15 | 1.1 | 0.8 | 0.2 | ||
| Dendritic cells (cDCs) percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 44 | 0.8 | 0.07 | 0.8 | 0.614 | |
| endogenous DNA damage level > 6.34 | 13 | 1.0 | 0.1 | 0.7 | ||
| Plasmocytoid dendritic cells (pDCs) percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 43 | 0.1 | 0.01 | 0.1 | 0.938 | |
| endogenous DNA damage level > 6.34 | 13 | 0.2 | 0.02 | 0.1 | ||
| CD16+ within DCs percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 32 | 41.5 | 2.8 | 44.4 | 0.00574 | 0.00010 |
| endogenous DNA damage level > 6.34 | 6 | 64.1 | 6.5 | 64.8 | ||
| CD1c+ within DCs percentage | ||||||
| endogenous DNA damage level ≤ 6.34 | 44 | 23.1 | 1.3 | 22.9 | 0.066 | |
| endogenous DNA damage level > 6.34 | 13 | 18.1 | 2.4 | 17.3 | ||
SEM, standard error of the mean. Values of p ≤ 0.05 are considered as significant. b Univariate analysis, c Multivariate logistic regression analysis.