Figure 3.

The first half of B cell lymphopoiesis happens inside the BM and results in immature IgM-expressing B cells in the periphery. Visual summary of the initial events that lead to the formation of IgM⁺ immature B cells and that happen inside the BM. Close control of differentiation and replication is needed to avoid malignant transformation during active Ig recombination. This is achieved through both tight metabolic regulation as well as sequential trafficking of the B cell lineage between specific BM niches (from the IL7-rich to the CXCL12 one). Bioenergetic swifts are of particular interest and are specifically shown in this diagram as orange (glycolysis) and blue (OxPhos) lines. IL7(R): Interleukin 7 (receptor), CXCR4: C-X-C Motif Chemokine Receptor 4, CXCL12: C-X-C Motif Chemokine Ligand 12. Created with BioRender.com.