Table 1.
Included studies of weaning in NAVA versus conventional modes of ventilation in children.
| Reference | Study Population | Type of Study | Outcome Measures | |||||
|---|---|---|---|---|---|---|---|---|
| Duration of Weaning | PICU Length of Stay | Sedative Use | Re-Intubation within 24 h | Mortality | Complications of Ventilation | |||
| Kallio 2015 [27] |
Invasively ventilated children 0–16 years, n = 170 | Randomised Controlled Trial |
Median 3.3 versus 6.6 h (NS) | Median 49.5 versus 72.8 h (p = 0.03, per-protocol analysis) | Mean difference in sedation units −1.43 units (95% CI −2.79 to −0.07; p = 0.03) | No difference n = 3 (NAVA group) vs. n = 4 (control) | No difference n = 0 (NAVA group) vs. n = 2 (control) | Accidental extubation n = 1 vs. n = 2 |
| Piastra 2014 [29] |
Children ventilated for ARDS, n = 30 | Cohort | Mean 41 (±17) versus 72.5 (±44) h (p = 0.011) | No difference | COMFORT score mean 18.1 (±2.1) vs. 25.3 (±7, p = 0.004) for same average dose | Not reported | No deaths during study period, 2 later deaths in each cohort | Not reported |
| Sood 2019 [30] |
Children recovering following cardiac surgery on CPB, n = 75 | Cohort | Median total ventilation days 9 (IQR 4) vs. 11 (IQR 7.5, p = 0.0128) | Median 9 days (IQR 4) versus 13.5 days (IQR 7.5, p < 0.0001) | Fentanyl days 9 (IQR 5) vs. 12.5 (IQR 7, p < 0.0001) Midazolam days 8 (IQR 4) vs. 12 (IQR 7, p < 0.0001) | 2.9 % vs. 20% (p = 0.032), OR for successful extubation 8.5 (95% CI 1.01 to 71.8) | Not reported | Not reported |
Abbreviations: NS = not significant; 95% CI = 95% confidence interval; CPB = cardiopulmonary bypass; IQR = interquartile range.