Table 1.

Exclusion criteria for corneal donor grafts of the Eye Bank of the University Medical Center Mainz, evaluated according to medical history ¹.

Postmortem interval >72 h. Diseases affecting the central nervous system: Multiple sclerosis; Amyotrophic lateral sclerosis; Alzheimer’s disease; Retroviral CNS disease; Parkinson’s disease; Risk for prion diseases. Active systemical infections (bacterial sepsis is no absolute contraindication, as bacterial contamination can be detected during tissue culture). Donors who had one of the following infections: HIV, hepatitis C, hepatitis B, HTLV I/II; Protozoonoses: babesiosis, trypanosomiasis (e.g., Chagas), leishmaniosis; Syphilis and other chronic bacterial infections. Donors who possibly had one of the following diseases: 2 years after infection with Salmonella thyphi/parathyphi; Recovery from Q fever, tuberculosis, leptospirosis; 4 years after recovery from malaria; 4 weeks after recovery from rubeola, rubella, varicella zoster, hepatitis, viral meningitis, viral encephalitis, viral hemorrhagic fever. Corneal/local infection from: Bacteria; Viruses; Parasites; Fungi. Malignant tumors of the ocular fundus (e.g., retinoblastoma, uveal melanoma). High risk for infection due to travel record. Exposure to cyanide, lead, mercury, gold. Shortly received vaccination with live vaccine with risk for transmission (e.g., rabies). Recipients of heterografts or xenografts. Hematological neoplasia (e.g., leukemia, lymphoma, MDS, MPN). Relative contraindication: Unknown cause of death; Hints for invalid blood tests due to hemodilution (massive transfusion); Refractive surgical procedures (e.g., LASIK, PRK).

¹ Aligned with German guidelines [25] modified according to the procedure of Mainz. CNS: central nervous system, MDS: myelodysplastic syndrome, MPN: myeloproliferative neoplasm, LASIK: laser-in-situ-keratomileusis, PRK: photorefractive keratectomy.