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Design of novel AAV2 based viral capsids via peptide insertion.
| Amino Acid Position | Original Sequence/Insertion | Novel rAAV |
|---|---|---|
| Sub491-501-GS4 | VSKT GGGS TPPRYRAD GGGS SWTG | rAAV-2E3.v2 |
| Sub510-514-GS4 | YHL GGGS TPPRYRAD GGGS DSL | rAAV-2E3.v3 |
| Ins588-GS4 | TNLQRGNR GGGS TPPRYRAD GGGS QAA | rAAV-2E3.v4 |
| Ins588 | TNLQRGNR GTPPRYRAD QAA | rAAV-2E3.v5 |
| Sub581-589-GS4 | T GGGS ITPPRYRAD GGGS QAA | rAAV-2E3.v6 |
