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. 2021 Jul 27;26(15):4521. doi: 10.3390/molecules26154521

Scheme 5.

Scheme 5

Thalicarpine (43) and 6a,7-dehydrothalicarpine (87) syntheses via the late-stage installation of the ether bond using a classical Ullman coupling reaction followed by DDQ (2,3-dichloro-5,6-dicyano-l,4-benzoquinone) oxidation.