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ADAM17 promotes idiopathic pulmonary fibrosis via EMT activation. Representative scheme illustrating the results of TGF-β-induced CTGF expression mediated via the ERK/ADAM17/RSK1/C/EBPβ pathway in human lung epithelial cells. TGF-β activates the ERK/ADAM17/RSK1/C/EBPβ signalling pathway, which finally leads to CTGF expression, promoting EMT in human lung epithelial cells.
