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. 2021 Aug 2;22(15):8300. doi: 10.3390/ijms22158300

Figure 7.

Figure 7

MiR-7-5p affect HIF-1α expression but not COX-2 and PFK expression. To reveal whether HIF-1α, COX-2, and PFK are involved in the resistance to radiotherapy and under control of miR-7-5p in CRR cells, qPCR was conducted. (A,B) Gene expression of HIF-1α. (C,D) Gene expression of COX-2. (E,F) Gene expression of PFK. (A,C,E) Gene expression of parent vs. CRR cells. (B,D,F) Gene expression of N.C. vs. miR-7-5p knockdown. HIF-1α, COX-2, and PFK were significantly up-regulated in CRR cells. However, only HIF-1α gene expression was regulated by miR-7-5p. *: p < 0.05, **: p < 0.01 using Student’s t-test. Each qPCR was performed 3 times.