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. 2021 Aug 2;22(15):8300. doi: 10.3390/ijms22158300

Figure 8.

Figure 8

Morphology of parent, CRR, NoIR, and simiR-7-5p cells. Morphology of the cells was observed under the optical microscope with 10× eyepieces and 10× objective lenses (magnification: 100×). (A) HeLa parental cells. (B) HeLa CRR cells. (C) HeLa CRR NoIR cells. (D) HeLa CRR cells that were knocked down by miR-7-5p. (E) SAS parental cells. (F) SAS CRR cells. (G) SAS CRR NoIR cells. (H) SAS CRR cells that were knocked down miR-7-5p. NoIR cells were cultured without 2 Gy/day irradiation for over 1 year and lost radioresistance. The cell shape of CRR cells looks small and tightly aggregated compared with that in parental cells. These characteristics are similar in NoIR cells, which lose radioresistance. Conversely, when miR-7-5p is knocked down, the cell–cell connections appear to loosen like the parental cells.