Table 2.
Correlation analysis of the metabolic role of the brain protein acetylatrion. Total acetylation of the brain proteins (AcK), SIRT3 and SIRT2 protein levels, enzymatic activities (act) related to PDHC, and redox metabolism are correlated to each other. Pearson’s correlation coefficients and p-values are presented in each cell of the table—above and below, respectively. The data obtained for the control rats and those which received thiamine are presented in the table parts below and above the diagonal line, correspondingly. Positive correlations are colored in red (p < 0.05), negative correlations are colored in blue (p < 0.05).
| Thiamine | AcK Total | SIRT3 | SIRT2 | PDHC act | OGDHC act | IDH act | GDH act | MDH act | ME act | CATA | THTM | ERO1A | PDIA1 | PDIA3 | PDIA6 | GSHR | TRXR1 | TXNL1 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | |||||||||||||||||||
| AcK | −0.11 0.65 |
−0.43 0.07 |
0.20 0.44 |
0.20 0.42 |
−0.06 0.83 |
−0.36 0.14 |
−0.55 0.02 |
−0.31 0.21 |
0.53 0.03 |
−0.42 0.08 |
−0.80 0.00 |
−0.27 0.27 |
−0.38 0.12 |
−0.62 0.01 |
−0.34 0.17 |
−0.42 0.08 |
0.42 0.08 |
||
| SIRT3 | 0.43 0.08 |
0.31 0.21 |
0.00 0.99 |
0.06 0.83 |
0.10 0.71 |
0.09 0.73 |
−0.23 0.36 |
0.13 0.61 |
−0.04 0.89 |
0.42 0.09 |
−0.04 0.88 |
0.22 0.38 |
0.41 0.09 |
0.24 0.33 |
0.18 0.48 |
0.28 0.26 |
0.25 0.32 |
||
| SIRT2 | −0.64 0.00 |
0.08 0.75 |
−0.21 0.41 |
−0.16 0.53 |
0.12 0.63 |
−0.02 0.94 |
0.28 0.26 |
0.62 0.01 |
−0.23 0.36 |
0.92 0.00 |
0.64 0.00 |
0.09 0.72 |
0.53 0.02 |
0.62 0.01 |
0.49 0.04 |
0.67 0.00 |
0.22 0.38 |
||
| PDHC act | 0.72 0.00 |
0.42 0.08 |
−0.45 0.06 |
0.09 0.73 |
−0.27 0.27 |
0.28 0.26 |
−0.25 0.32 |
−0.47 0.05 |
0.49 0.04 |
−0.24 0.34 |
−0.08 0.75 |
−0.25 0.31 |
−0.26 0.29 |
−0.23 0.36 |
−0.46 0.05 |
−0.30 0.23 |
−0.29 0.24 |
||
| OGDHC act | 0.72 0.00 |
0.18 0.46 |
−0.66 0.00 |
0.29 0.24 |
0.24 0.34 |
−0.10 0.69 |
−0.50 0.04 |
−0.52 0.03 |
0.15 0.56 |
−0.29 0.24 |
−0.31 0.22 |
0.42 0.08 |
0.14 0.57 |
−0.15 0.54 |
−0.05 0.86 |
−0.07 0.79 |
0.19 0.44 |
||
| IDH act | 0.22 0.37 |
−0.09 0.72 |
−0.53 0.02 |
0.33 0.18 |
0.15 0.56 |
0.09 0.73 |
−0.14 0.57 |
−0.04 0.87 |
−0.06 0.81 |
0.05 0.83 |
−0.18 0.48 |
0.14 0.59 |
0.04 0.88 |
−0.10 0.68 |
0.09 0.73 |
0.00 1.00 |
−0.03 0.89 |
||
| GDH act | 0.07 0.78 |
0.31 0.21 |
0.03 0.92 |
0.17 0.50 |
−0.05 0.85 |
0.22 0.38 |
0.00 0.99 |
−0.01 0.98 |
−0.12 0.63 |
0.02 0.95 |
0.17 0.50 |
0.03 0.92 |
−0.22 0.37 |
−0.04 0.87 |
−0.32 0.19 |
−0.30 0.22 |
−0.63 0.01 |
||
| MDH act | −0.56 0.02 |
−0.44 0.06 |
0.52 0.03 |
−0.57 0.01 |
−0.47 0.05 |
−0.28 0.26 |
0.15 0.54 |
0.66 0.00 |
−0.28 0.26 |
0.26 0.30 |
0.71 0.00 |
0.03 0.92 |
0.28 0.26 |
0.59 0.01 |
0.44 0.07 |
0.42 0.08 |
−0.31 0.21 |
||
| ME act | −0.58 0.01 |
−0.26 0.30 |
0.36 0.15 |
−0.65 0.00 |
−0.19 0.44 |
−0.31 0.21 |
−0.49 0.04 |
0.40 0.10 |
−0.15 0.55 |
0.69 0.00 |
0.51 0.03 |
−0.03 0.91 |
0.31 0.22 |
0.48 0.04 |
0.45 0.06 |
0.44 0.07 |
−0.05 0.85 |
||
| CATA | 0.63 0.00 |
0.62 0.01 |
−0.31 0.21 |
0.34 0.17 |
0.62 0.01 |
0.17 0.51 |
0.51 0.03 |
−0.35 0.16 |
−0.42 0.09 |
−0.31 0.21 |
−0.39 0.11 |
−0.45 0.06 |
−0.35 0.15 |
−0.52 0.03 |
−0.43 0.07 |
−0.38 0.12 |
0.07 0.78 |
||
| THTM | −0.43 0.08 |
0.31 0.21 |
0.90 0.00 |
−0.30 0.23 |
−0.52 0.03 |
−0.36 0.15 |
0.02 0.93 |
0.28 0.27 |
0.25 0.32 |
−0.14 0.58 |
0.57 0.01 |
0.03 0.89 |
0.47 0.05 |
0.56 0.01 |
0.43 0.08 |
0.58 0.01 |
0.17 0.51 |
||
| ERO1A | −0.50 0.03 |
−0.03 0.92 |
0.62 0.01 |
−0.28 0.26 |
−0.46 0.06 |
−0.39 0.11 |
0.23 0.36 |
0.62 0.01 |
0.32 0.19 |
−0.22 0.39 |
0.48 0.04 |
0.26 0.30 |
0.55 0.02 |
0.80 0.00 |
0.52 0.03 |
0.63 0.01 |
−0.25 0.32 |
||
| PDIA1 | −0.53 0.02 |
−0.04 0.89 |
0.14 0.59 |
−0.53 0.02 |
−0.25 0.33 |
−0.05 0.85 |
0.10 0.69 |
0.31 0.22 |
0.54 0.02 |
−0.12 0.63 |
0.15 0.54 |
0.48 0.04 |
0.76 0.00 |
0.55 0.02 |
0.69 0.00 |
0.56 0.02 |
0.02 0.93 |
||
| PDIA3 | −0.40 0.10 |
0.14 0.58 |
0.20 0.42 |
−0.39 0.11 |
−0.21 0.39 |
−0.06 0.80 |
−0.03 0.89 |
0.25 0.32 |
0.50 0.03 |
−0.13 0.60 |
0.25 0.31 |
0.58 0.01 |
0.87 0.00 |
0.85 0.00 |
0.90 0.00 |
0.92 0.00 |
0.28 0.26 |
||
| PDIA6 | −0.53 0.02 |
0.01 0.97 |
0.43 0.07 |
−0.48 0.04 |
−0.37 0.13 |
−0.28 0.27 |
0.25 0.31 |
0.53 0.02 |
0.45 0.06 |
−0.20 0.43 |
0.38 0.12 |
0.82 0.00 |
0.81 0.00 |
0.83 0.00 |
0.83 0.00 |
0.90 0.00 |
0.01 0.98 |
||
| GSHR | −0.46 0.06 |
0.00 0.99 |
0.17 0.49 |
−0.28 0.27 |
−0.41 0.09 |
0.00 1.00 |
−0.18 0.48 |
0.18 0.47 |
0.46 0.05 |
−0.45 0.06 |
0.21 0.39 |
0.44 0.07 |
0.78 0.00 |
0.89 0.00 |
0.71 0.00 |
0.93 0.00 |
0.22 0.38 |
||
| TRXR1 | −0.57 0.01 |
0.00 0.99 |
0.37 0.13 |
−0.56 0.02 |
−0.30 0.23 |
−0.22 0.39 |
−0.03 0.92 |
0.45 0.06 |
0.63 0.00 |
−0.22 0.38 |
0.35 0.16 |
0.67 0.00 |
0.91 0.00 |
0.94 0.00 |
0.90 0.00 |
0.82 0.00 |
0.27 0.27 |
||
| TXNL1 | 0.05 0.85 |
−0.23 0.36 |
−0.21 0.39 |
−0.16 0.53 |
0.09 0.72 |
0.22 0.37 |
−0.71 0.00 |
−0.12 0.63 |
0.40 0.10 |
−0.19 0.46 |
−0.04 0.87 |
−0.23 0.37 |
0.21 0.41 |
0.28 0.26 |
−0.10 0.69 |
0.32 0.20 |
0.20 0.42 |
||