Skip to main content
. 2021 Jul 21;10(15):3211. doi: 10.3390/jcm10153211

Figure 2.

Figure 2

Microarray Transcriptomic Analysis of Leukocytes from Rapid Recovery and CCI patients. The genomic response of isolated total leukocyte RNA in healthy controls and sepsis patients. (A) Conditional principal component analysis of sepsis and healthy control leukocyte gene expression patterns from genes that had a log2 variation > 0.4 (see Materials and Methods). Each shape represents genomic expression of one group at a specific time-point. PC1 explains 31.4%, PC2, 17.6% and PC3, 10.4% of the total variation. It is in the PC2–PC3 analysis that the differences in gene expression at day 14 are most evident between patients with rapid recovery and those with CCI. (B) Heat map (log2) of the leukocyte gene expression patterns and variation between CCI and rapid recovery patients at day 1 and day 14 versus healthy control subjects on significant differentially expressed genes. Note the pattern of expression in rapid recovery at day 14 is closer to control than CCI at day 14, consistent with the PC2–PC3 mapping in (panel A). CCI = chronic critical illness patients, RAP = rapid recovery patients, PC = principal component.