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. 2021 Aug 2;22(15):8299. doi: 10.3390/ijms22158299

Figure 3.

Figure 3

The effect of ciclopirox on ovariectomy (OVX)-induced bone loss in vivo. (A) Representative image of the trabecular region of interest (ROI: 0.21–1.94 mm from the growth plate) and three-dimensional images of the tibial trabecular bone were obtained. (B) Morphometric analysis of the trabecular bone in each group. Bone mineral density (BMD), bone volume fraction (BV/TV), trabecular number (Tb. N), and trabecular separation (Tb. Sp) were measured. Control n = 5; OVX n = 6; OVX + C 5 mg/kg n = 6; OVX + E2 n = 5. (C) Representative images of Acid Phosphatase, Leukocyte (TRAP)-stained tibial sections. (D) Quantitation of TRAP-positive cells in the proximal tibia. Scale bar, 100 μm. * p < 0.05, ** p < 0.01 (analysis of variance with Tukey’s post hoc). E2: 17β-estradiol, C: ciclopirox.