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The schematic representation of endocannabinoid action on presynaptic Ca2+ channels. Endocannabinoids synthesized postsynaptically act on presynaptic CB1/CB2 receptors coupled to Gi/o, which may decrease cAMP level by inhibiting adenylyl cyclase (AC). The βγ inhibits L, N and P/Q-type calcium channels but activates inwardly, rectifying the potassium channel (KiR, yellow arrow). Inhibitory action is indicated by the red arrow.
