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. 2021 Jul 30;10(15):3388. doi: 10.3390/jcm10153388

Figure 4.

Figure 4

Dose-response associations between RC and cardiovascular outcomes for subgroups aged < 65 years and DM. Restricted cubic splines displaying the lnHRs of cardiovascular events among participants aged < 65 years (A(1–4)) and diabetes (B(1–4)) with 95% confidence intervals according to the serum level of remnant cholesterol. Reference set to medians (0.83 mmol/L for subgroups aged < 65 years, 0.95 mmol/L for the diabetes mellitus subgroup). Knots located at the 5th, 50th, and 95th percentiles of remnant cholesterol (subgroup aged < 65 years: 0.17, 0.83, and 1.57 mmol/L; DM: 0.25, 0.95, and 1.76 mmol/L). Adjusted for age, sex, ethnicity, body mass index, smoking status, drinking status, hypertension, DM, estimated glomerular filtration rate, hyperuricemia, and continuous triglyceride. CHD, coronary heart disease; CVD, cardiovascular disease; DM, diabetes mellitus; HR, hazard ratio; lnHRs, natural log of hazard ratios; RC, remnant cholesterol; SD, standard deviation.