Table 2.
Differences in the median of lymphocyte subpopulations and absolute numbers between (a) the CVID with complicated phenotype (CVID-C) group, (b) CVID phenotype limited to only infections (CVID-OI group), (c) patients with systemic lupus erythematosus (SLE), and (d) healthy controls (HCs). Data expressed as median (Q1–Q3). * p < 0.05. ANOVA: analysis of variance, Post Hoc: post hoc analysis tests.
| As Median (Q1–Q3) |
CVID-C (a) n = 24 |
CVID-OI (b) n = 9 |
SLE (c) n = 17 |
HC (d) n = 20 |
p < 0.05 Group a-b-c-d ANOVA, Kruskal–Wallis | p < 0.05 between Groups Post Hoc Test |
|---|---|---|---|---|---|---|
| % of all cells | ||||||
| Lymphocytes | 21.0 (16.6–29.8) |
27.5 (22.7–36.3) |
28.4 (12.1–36.6) |
38.3 (33.2–46.3) |
p = 0.0002 | *a-d, *c-d |
| Lymphocytes T | 17.6 (15.7–23.7) |
22.4 (19.5–25.9) |
19.3 (8.7–27.4) |
29.5 (24.0–37.2) |
p = 0.0011 | *a–d, *c–d |
| CD4 cells | 9.1 (4.3–11.4) |
8.9 (6.8–9.9) |
9.8 (4.9–12.0) |
18.6 (13.6–22.0) |
p < 0.0001 | *a–d, *b–d, *c–d |
| CD8 cells | 9.8 (7.0–12.0) |
11.6 (8.3–11.9) |
9.1 (3.3–11.5) |
10.5 (7.8–13.2) |
- | - |
| Lymphocytes B | 0.8 (0.1–2.2) |
3.3 (1.0–3.4) |
2.4 (1.5–5.7) |
3.9 (3.0–5.0) |
p < 0.0001 | *a–c, *a–d |
| NK cells | 1.0 (0.5–1.9) |
1.8 (1.4–2.3) |
3.0 (2.0–3.7) |
4.2 (2.8–7.0) |
p = 0.0001 | *a–d |
| Bregs | 0.023 (0.008–0.113 |
0.050 (0.037–0.106) |
0.041 (0.016–0.059) |
0.065 (0.049–0.093) |
- | - |
| Tregs | 0.209 (0.093–0.366) |
0.404 (0.356–0.613) |
0.265 (0.167–0.478) |
0.824 (0.711–1.109) |
p < 0.0001 | *a–d, *c–d |
| Th17 | 2.3 (1.0–4.3) |
2.2 (1.8–3.7) |
1.1 (0.4–1.9) |
5.0 (3.8–7.1) |
p < 0.0001 | *a–d, *c–d |
| (cells/µL) | ||||||
| WBC | 5575 (4605–7555) |
6600 (5440–7370) |
5690 (3630–8310) |
6555 (4930–7535) |
- | - |
| Lymphocytes | 1201 (755–2145) |
1986 (1119–2402) |
1115 (1005–1576) |
2037 (1838–2934) |
p = 0.0002 | *a–d, *c–d |
| Lymphocytes T | 1071 (701–1614) |
1457 (961–2093) |
887 (570–1125) |
1660 (1409–2292) |
p = 0.0004 | *a–d, *c–d |
| CD4 cells | 458 (305–553) |
574 (372–680) |
418 (288–499) |
978 (756–1559) |
p < 0.0001 | *a–d, *c–d |
| CD8 cells | 580 (305–809) |
814 (374–1089) |
319 (162–582) |
624 (457–791) |
p = 0.0269 | *c–d |
| Ratio CD4/CD8 | 0.8 (0.4–1.2) |
0.8 (0.4–1.0) |
1.3 (0.9–1.7) |
1.8 (1.5–2.5) |
p = 0.0003 | *a–d, *b–d |
| Lymphocytes B | 47 (12–127) |
212 (117–332) |
145 (69–222) |
216 (190–284) |
p < 0.0001 | *a–d |
| NK cells | 54 (32–100) |
152 (96–488) |
126 (87–234) |
245 (204–447) |
p = 0.0001 | *a–d |
| Bregs | 1 (0–4) |
4 (2–9) |
2 (1–3) |
4 (3–7) |
- | - |
| Tregs | 15 (4–21) |
26 (22–30) |
20 (12–28) |
55 (37–82) |
p < 0.0001 | *a–d, *c–d |
| Th17 | 130 (73–190) |
131 (94–284) |
77 (35–113) |
256 (209–494) |
p < 0.0001 | *a–d, *c–d |