Table 3.
Differences in the proportions of B lymphocyte maturation between (a) the CVID with complicated phenotype (CVID-C) group, (b) CVID phenotype limited to only infections (CVID-OI group), (c) patients with systemic lupus erythematosus (SLE), and (d) healthy controls (HCs). Data expressed as median (Q1–Q3). * p < 0.05. ANOVA: analysis of variance, Post Hoc: post hoc analysis tests.
| As Median (Q1–Q3) |
CVID-C (a) n = 24 |
CVID-OI (b) n = 9 |
SLE (c) n = 17 |
HC (d) n = 20 |
p < 0.05 Group a-b-c-d ANOVA, Kruskal–Wallis | p < 0.05 between Groups Post Hoc Test |
|---|---|---|---|---|---|---|
| % of B cells | ||||||
| Transitional B | 4.3 (1.9–8.4) |
5.5 (2.4–21.6) |
2.1 (1.0–6.2) |
1.8 (1.4–2.3) |
p = 0.0149 | *b–d |
| Naïve B | 56.3 (24.6–71.5) |
54.8 (48.8–81.3) |
51.0 (46.0–73.4) |
68.0 (63.5–73.1) |
- | - |
| Nonswitched memory | 15.9 (8.9–38.7) |
11.0 (8.8–28.7) |
6.0 (3.7–11.1) |
8.6 (6.9–10.3) |
p = 0.0036 | *a–c, *a–d |
| Class-switched memory | 2.2 (0.2–3.7) |
0.6 (0.3–1.3) |
18.4 (8.6–28.2) |
17.6 (12.7–22.8) |
p < 0.0001 | *a–c, *a–d, *b–c, *b–d |
| Plasmablasts | 0.5 (0.1–1.4) |
0.5 (0.1–1.1) |
3.9 (1.3–7.8) |
1.4 (0.8–1.6) |
p = 0.0004 | *a–c, *b–c |
| CD21low B cells | 2.2 (0.9–6.7) |
2.5 (0.8–6.5) |
1.3 (0.9–1.9) |
0.6 (0.4–0.9) |
p = 0.0005 | *a–d, *b–d |
| Transitional B | 4.3 (1.9–8.4) |
5.5 (2.4–21.6) |
2.1 (1.0–6.2) |
1.8 (1.4–2.3) |
p = 0.0149 | *b–d |
| Naïve B | 56.3 (24.6–71.5) |
54.8 (48.8–81.3) |
51.0 (46.0–73.4) |
68.0 (63.5–73.1) |
- | - |
| Nonswitched memory | 15.9 (8.9–38.7) |
11.0 (8.8–28.7) |
6.0 (3.7–11.1) |
8.6 (6.9–10.3) |
p = 0.0036 | *a–c, *a–d |