Table A2.

Summary of the major studies evaluating the association between OSA and ischemic optic neuropathy.

Author, Year	Country/Region	Sample Size	Main Findings
Stein, 2011 [34]	USA	2,257,163	OSA patients without CPAP therapy had a significantly increased risk of NAION (HR (95% CI): 1.16 (1.01–1.33), p < 0.001). There was no significant difference in the risk of NAION between OSA patients treated with CPAP and non-OSA patients.
Huon, 2016 [37]	USA	274	A meta-analysis of 4 case–control studies showed that OSA was significantly associated with the development of NAION (pooled OR (95% CI): 3.126 (1.799–5.433), p < 0.001).
Wu, 2016 [37]	China	5,916	A meta-analysis of 4 prospective cohort studies and 1 case–control study demonstrated higher incidence of NAION in OSA individuals vs. non-OSA controls (pooled OR (95% CI): 6.18 (2.00–19.11), p = 0.002).
Liguori, 2018 [67]	Italy	20	Stringently adherent CPAP therapy significantly improved VEP in patients with OSA.
Sun, 2019 [63]	Taiwan	42,440	OSA was a significant risk factor for the development of NAION (HR (95% CI): 1.66 (1.08–2.55), p = 0.019).
Chang, 2019 [66]	USA	318	Poor compliance with CPAP therapy in patients with moderate-to-severe OSA was a major risk factor of NAION in the fellow eye (HR (95% CI): 4.50 (1.79–11.3), p = 0.0015).