Figure 4.

MuSK agonist antibody#13 increases the size of splenius muscle in SMA mice. (A) Images of cross-sections of PND14 SMA splenius muscles without (a,b)—white inset box in (a) is enlarged in (b)—and with (c,d)—white inset box in (c) is enlarged in (d)—MuSK agonist antibody #13 treatments. Scale bars: 40 µm in (a,c); 20 µm in (b,d). (B) Quantitation of the cross-sectional area (a), myofiber number (b), and myofiber size (c) in the PND 14 splenius muscle of WT, delta7 SMA mice without and with MuSK agonist antibody #13 treatments. The distributions of myofiber size (d) and number of myofiber less and greater than 100 µm² (e) of PND 14 delta7 SMA mice are also shown. Values are expressed as mean ± SEM, * p < 0.05, ** p < 0.01 and *** p < 0.001.