Figure 1.

Inhibitory effects of ECE and DK on the relative binding levels of RAGE-AGE, RAGE-HMGB1, TLR4-AGE, and TLR4-HMGB1 in the gastrocnemius muscle of the Dexa-induced muscle atrophy model. The relative binding levels of RAGE-AGE (a), RAGE-HMGB1 (b), TLR4-AGE (c), and TLR4-HMGB1 (d) were increased by Dexa but decreased by ECE and DK treatment. The dose unit of ECE and DK is mg/kg/day. a–e: Different letters indicate significant differences among groups as determined by multiple comparison (Mann–Whitney U test); p < 0.05. AGE, advanced glycation end products; Dexa, dexamethasone; DK, dieckol; ECE, Ecklonia cava extract; HMGB1, high mobility group box 1; RAGE, receptor of AGE; TLR4, toll like receptor 4.