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. 2021 Jul 28;22(15):8057. doi: 10.3390/ijms22158057

Figure 2.

Figure 2

Inhibitory effects of ECE and DK on NF-κB activation in the gastrocnemius muscle of the Dexa-induced muscle atrophy model. (a,b) Protein levels of NF-κB activation-related molecules (SAPK/JNK and p38) were determined by Western blotting. As a result, the ratios of p-SAPK/JNK to JNK and p-p38 to p38 were increased by Dexa but decreased by ECE and DK treatment. (c,d) The amount of NF-κB translocated into the nucleus was increased by Dexa but decreased by ECE and DK treatment. The dose unit of ECE and DK is mg/kg/day. a–e: Different letters indicate significant differences among groups, as determined by multiple comparison (Mann–Whitney U test); p < 0.05. Dexa, dexamethasone; DK, dieckol; ECE, Ecklonia cava extract; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; SAPK/JNK, stress-activated protein kinase/Jun-amino-terminal kinase; p-SAPK/JNK, phospho-SAPK/JNK; p-p38, phopho-p38.