Figure 2.

Resveratrol-induced SIRT1 is associated with a modulation of various mechanisms of age-related pathologies. Resveratrol stimulates binding between FoxO1 and SIRT1, and it may reduce kidney damage, myocyte hypertrophy, cellular senescence, oxidative stress, tubular apoptosis, and interstitial fibrosis. It also stimulates cellular differentiation and autophagy through SIRT1 activation. All of these pathways are involved in the higher potency of resveratrol against the aging process. Arrow means activation, and ‘T’ arrow means inhibition.