Figure 3.

Resveratrol-induced AMPK is associated with the modulation of various mechanisms of age-related pathologies. Resveratrol-induced AMPK activates SIRT1, leading to the inhibition of many age-related pathologies. AMPK suppresses EMT and fibrosis through inhibition of mTOR. Nrf2, and SOD expression, which is associated with the activation of autophagy and the suppression of oxidative stress. Additionally, AMPK lowers blood pressure and increases mitochondrial biogenesis-related genes, such as Nrf1, Tfam, and PGC-1α. All of these pathways mediated by resveratrol-induced AMPK are associated with the anti-aging process. AMP-activated protein kinase, AMPK; epithelial–mesenchymal transition, EMT; sirtuin type 1, SIRT1; mammalian target of rapamycin, mTOR; mitochondrial uncoupling protein2 (UCP2); nuclear factor erythroid 2–related factor 2 (Nrf2); peroxisome proliferator-activated receptor-γ coactivator-1α, PGC-1α; and mitochondrial transcription factor A, Tfam. Arrow means activation, and ‘T’ arrow means inhibition.