Table 5.

The 5 most significant pathways enriched by 224 genes with altered transcription factors-motif binding sites. The table shows the pathway name, p-value and the genes of our list that are involved in that pathway.

Pathway Name	p-Value	Submitted Entities Found
Regulation of beta-celldevelopment	6.661 × 10−16	NR5A2, HNF4A, HNF6, HES1, HNF1B, STF1, HNF1A, FOXA3, FOXO1, FOXA2
Generic Transcription Pathway	9.880 × 10−15	SPI1, RORA, NR2E3, BACH1, GLI2, MECP2, RORG, HNF4A, SOX9, TEAD1, TEAD3, TEAD4, MSX2, PAX5, ERR1, P73, RUNX3, FOXP3, RUNX2, FOXP2, RUNX1, ELF1, NR5A2, TAL1, DDIT3, PPARG, PPARD, NR1I3, TCF7, LEF1, FOXO4, FOXO3, NR2C2, FOXO1, RXRA, HES1, RXRG, E2F6, SMAD2, NFE2, SMAD1, SMAD4, ZFHX3, SMAD3, NFYA, NFYB, VDR, NFYC, NR1H2, NR1H4, NR0B1, NR1D1, TBX5, NR2F6, NR4A3, SP1
Transcriptional regulation by RUNX3	7.648 × 10−10	SPI1, RORA, NR2E3, BACH1, GLI2, MECP2, RORG, HNF4A, SOX9, TEAD1, TEAD3, TEAD4, MSX2, PAX5, ERR1, P73, RUNX3, FOXP3, RUNX2, FOXP2, RUNX1, ELF1, NR5A2, TAL1, DDIT3, PPARG, PPARD, NR1I3, TCF7, LEF1, FOXO4, FOXO3, NR2C2, FOXO1, RXRA, HES1, RXRG, E2F6, SMAD2, NFE2, SMAD1, SMAD4, ZFHX3, SMAD3, NFYA, NFYB, VDR, NFYC, NR1H2, NR1H4, NR0B1, NR1D1, TBX5, NR2F6, NR4A3, SP1
Transcriptional regulation of pluripotent stem cells	5.635 × 10−7	SMAD2, FOXD3, SMAD4, EPAS1, STAT3, PBX1
FOXO-mediated transcription of cell death genes	6.742 × 10−7	NFYA, NFYB, DDIT3, NFYC, FOXO4, FOXO3, FOXO1