Table 1.

Advantages and disadvantages of tissue and biofluid-based proteomics for the detection of blood cancer-associated biomarkers.

Tissue-Based Proteomics		Biofluid-Based Proteomics
Advantages	Disadvantages	Advantages	Disadvantages
Direct analysis of proteins from site of disease	Invasive procedure	Non-invasive	Not in direct proximity to the site of disease
Facilitates the study of the bone marrow microenvironment	Localised sampling bias due to heterogeneity of the bone marrow microenvironment	Ease of longitudinal sampling	High abundance proteins can hamper detection
Gold standard for diagnostic and prognostic applications	High cost	Low cost
	Bone marrow biopsies can be painful procedures	Reflective of disease state