Table 2.

Measures of blood flow and fetal growth as assessed by 90 dGA Doppler velocimetry and 130 dGA ³H₂0 transplacental diffusion.

	CON RNAi	CSH RNAi	% Change	p-Value
90 dGA Doppler Ultrasound Measurements	(n = 6)	(n = 6)
Binocular distance, cm	4.91 ± 0.25	4.63 ± 0.19	5.70	0.48
Biparietal circumference, cm	16.56 ± 0.63	15.11 ± 0.54	8.72	0.19
Abdominal circumference, cm	22.03 ± 0.95	20.30 ± 1.27	7.82	0.40
Femur length, cm	4.24 ± 0.08	4.17 ± 0.09	1.81	0.62
Tibia length, cm	3.05 ± 0.11	3.03 ± 0.04	0.75	0.87
Pulsatility Index	1.98 ± 0.16	2.04 ± 0.14	2.88	0.84
Resistance Index	0.69 ± 0.04	0.70 ± 0.02	1.12	0.89
Systolic:Diastolic	3.63 ± 0.34	3.59 ± 0.28	0.97	0.95
Fetal heart rate, bpm	190.48 ± 3.38	199.81 ± 8.91	4.90	0.48
Umbilical artery cross-sectional area, cm2	0.24 ± 0.02	0.18 ± 0.02	25.23	0.09
Umbilical artery cross-sectional diameter, cm	0.55 ± 0.02	0.47 ± 0.03	15.31	0.08
130 dGA Transplacental Diffusion Blood Flow Measurements	(n = 4)	(n = 4)
Uterine plasma flow (mL/min)	1417.74 ± 328.48	807.99 ± 208.40	43.01	0.17
Relative uterine blood flow (mL/min/kg fetus)	500.07 ± 86.44	400.98 ± 59.35	19.81	0.38
Relative uterine plasma flow (mL/min/kg fetus)	348.20 ± 61.93	274.78 ± 41.11	21.09	0.36
Uterine blood flow/100 g placenta	429.05 ± 54.03	320.80 ± 59.32	25.23	0.23
Umbilical plasma flow (mL/min)	490.84 ± 52.03	293.18 ± 63.87	40.27	0.05
Relative umbilical blood flow (mL/min/kg fetus)	185.35 ± 8.81	155.61 ± 11.26	16.04	0.08
Relative umbilical plasma flow (mL/min/kg fetus)	123.17 ± 8.27	101.08 ± 12.74	17.93	0.20
Umbilical blood flow/100 g placenta	163.27 ± 14.51	123.84 ± 13.63	24.15	0.09
Uterine: umbilical blood flow	2.68 ± 0.37	2.58 ± 0.37	3.74	0.85
Average umbilical arterial hematocrit	0.34 ± 0.02	0.36 ± 0.04	6.25	0.65
Average uterine arterial hematocrit	0.30 ± 0.01	0.31 ± 0.02	2.94	0.64

Data are shown as means ± SEM for all pregnancies in each treatment group. CSH, chorionic somatomammotropin; RNAi, RNA interference.