Table 4.

In vivo measurements of nutrient transfer and uptake based on the ³H₂0 transplacental diffusion technique.

130 dGA Nutrient Uptakes	CON RNAi	CSH RNAi	% Change	p-Value
	(n = 4)	(n = 4)
Relative umbilical oxygen uptake (mmol/min/kg fetus)	0.33 ± 0.01	0.29 ± 0.02	12.25	0.07
Relative uterine oxygen uptake (mmol/min/kg uterus)	3.18 ± 0.54	2.96 ± 0.45	6.93	0.76
Relative uteroplacental oxygen utilization (mmol/min/kg placenta)	2.78 ± 0.42	1.90 ± 0.25	31.61	0.12
Relative umbilical glucose uptake (μmol/min/kg fetus)	34.07 ± 2.98	24.75 ± 2.70	27.36	0.06
Glucose transferred per placental weight (μmol/kg/min)	301.82 ± 41.64	199.24 ± 32.59	33.99	0.10
Relative uterine glucose uptake (μmol/min/kg uterus)	515.33 ± 85.74	461.76 ± 70.98	10.39	0.65
Relative uteroplacental glucose utilization (μmol/min/kg placenta)	634.00 ± 59.81	472.72 ± 76.49	25.44	0.15
Umbilical lactate uptake (μmol/min)	123.16 ± 5.97	75.52 ± 16.11	38.68	0.03
Relative umbilical lactate uptake (μmol/min/kg fetus)	31.23 ± 1.78	26.26 ± 2.37	15.91	0.14
Uterine lactate secretion (μmol/min)	134.17 ± 1.78	−80.41 ± 154.00	159.93	0.22
Relative uterine lactate secretion (μmol/min/kg uterus)	301.02 ± 49.60	−518.48 ± 692.82	272.24	0.28
Uteroplacental lactate production (μmol/min)	257.33 ± 16.19	−4.89 ± 168.14	101.90	0.17
Relative uteroplacental lactate production (μmol/min/kg placenta)	576.83 ± 68.83	−311.58 ± 705.10	154.02	0.26

Data are shown as means ± SEM for all pregnancies in each treatment group. CSH, chorionic somatomammotropin; RNAi, RNA interference.