Table 3.

Medical therapies, uses, and level of evidence of current available treatments in patients with CVD.

Treatment	Uses	Level of Evidence and Recommendation
Compression therapy (stockings, bandages, adjustable compression wraps)	Initial therapeutical method of CVD A powerful tool in CVI ulceration Increase the efficacy after interventional procedures	IB [303] IB [305] IA [307,308]
Pharmacological therapies	Venotonics to ameliorate early symptoms (Pain, edema) Flavonoids and derivates as complement therapy with compression stockings in venous ulcers	IIaA [310] IIaA [311,316]
Sclerotherapy	Second-line treatment for patients who are not candidates for endovenous ablation or surgery First-line therapy in patients with recurrent CVD and fragile patients with venous ulceration	IA [319] IIaB [320]
Endovenous thermal ablation	First line therapy for patients with CVD and great saphenous vein reflux	IA [318,328]