Figure 4.
Histopathology of dedifferentiated liposarcoma. (A) Abrupt transition from well-differentiated liposarcoma (WDL)/atypical lipomatous tumor (ALT) to high-grade non-lipogenic sarcoma is seen. (B) Multivacuolated lipoblast can be seen in the WDL/ALT area. (C) The dedifferentiated component consists of atypical spindle cells, round to polygonal cells and bizarre giant cells, resembling myxofibrosarcoma. (D) MDM2 expression in the dedifferentiated area.
