Table 2.
Biomarkers associated with UC and their utility in various areas.
| Biomarker |
Distinguish UC from CD |
Predict IVCS Failure |
Predict IFX Failure |
Predict Long-Term Colectomy |
|---|---|---|---|---|
| CRP | - | + | + | + |
| Fecal calprotectin and lactoferrin | - | + | + | ~ |
| S100A12 | - | ~ | ~ | ~ |
| Fecal myeloperoxidase | - | ~ | ~ | ~ |
| Serologies | + | ~ | + | ~ |
| Drug-related biomarkers | - | ~ | + | ~ |
| Peripheral eosinophilia | ~ | + | ~ | + |
| Procalcitonin | ~ | + | ~ | ~ |
| Hypoalbuminemia | - | + | + | + |
| CRP/Albumin ratio | - | + | ~ | + |
| NLR and PLR | - | ~ | + | ~ |
+ indicates evidence demonstrating an association between the outcome and biomarker. - indicates evidence that the biomarker is not associated with the outcome. ~ indicates no evidence regarding association between the biomarker and the outcome. UC = Ulcerative colitis; CD = Crohn’s disease; IVCS = intravenous corticosteroids; IFX = infliximab; CRP = C-reactive protein; NLR = Neutrophil-to-lymphocyte ratio; PLR = Platelet-to-lymphocyte ratio.