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Involvement of NUCB2/NESF-1 in cancer-related processes. NUCB2/NESF-1 may stimulate cancer cell proliferation and apoptosis via the mTOR signaling cascade. NUCB2/NESF-1 also enhances EMT and cancer cell invasion by regulating gene expression associated with these processes, such as TWIST, Slug, and MMP-2 or MMP-9. On the other hand, NUCB2/NESF-1 plays the role of a tumor suppressor promoting apoptosis and in cancer cells via mTOR and RhoA/ROCK pathways.
