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. 2021 Jul 25;22(15):7924. doi: 10.3390/ijms22157924

Figure 1.

Figure 1

Background of the study. (a) Undisturbed intercellular communication between germ cells (GC) and Sertoli cells (SC) via Connexin43 (Cx43)-based gap junctions (GJ) results in normal spermatogenesis. (b) Knockout (KO) of Cx43 in SC leads to severely impaired spermatogenesis in SC specific Cx43 KO (SCCx43KO) mice. (c) The testicular phenotype of mice, which exhibit a KO of Cx43 in premeiotic or meiotic GC populations, is not confirmed, so far [38]. It is of interest to know, if a GC specific KO of Cx43 leads to a similar phenotype as the KO in SC. Scale bars = 50 µm.