Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 25;22(15):7924. doi: 10.3390/ijms22157924

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Hypothetical explanatory model of heterotypic Sertoli cell (SC)-germ cell (GC) gap junctional intercellular communication (GJIC). (a) In wild type (WT) mice, GJIC is undisturbed resulting in normal spermatogenesis; (b) SC specific knockout (KO) of Cx43 leads to impaired GJIC between SC and GC as the Connexin43 (Cx43)-based hemichannel of the heterotypic gap junction channel is missing in SC specific Cx43 KO (SCCx43KO) mice; (c) GJIC via heterotypic hemichannels remains unaffected, when Cx43 is deleted in premeiotic or meiotic GC (GCCx43KO).