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CCL19, CCL21, and Tailless-CCL21 (Tailless) induce differential signaling through their common receptor CCR7. Overall, CCL19 is a strong agonist of both G-protein signaling, β-arrestin recruitment, and chemotaxis, whereas CCL21 is a weak agonist. Upon cleavage by DC-released proteases, CCL21 is turned into Tailless-CCL21, which resembles CCL19 and, thus, is a strong agonist.
