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. 2021 Aug 6;16:14. doi: 10.1186/s13062-021-00298-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — p53 in the control of mRNA stability. p53 can transcriptionally regulate Zmat3 by binding a p53-responsive element in the first intron of Zmat3 gene. Zmat3 is localised in the nucleus and can bind AU-rich region of CD44 mRNAs. The binding on the long and oncogenic CD44 isoform (CD44v) promotes its degradation by mRNA decay process. Conversely, by binding the shorter and non-oncogenic isoform (CD44s) Zmat3 promotes the mRNA stabilization. In this context, modulating the expression of Zmat3, p53 regulates the balance of CD44 isoforms