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. 2021 Aug 7;40:248. doi: 10.1186/s13046-021-02049-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — HSPD1 knockdown induces a metabolic impairment and reduces tumor growth in vivo. Quantification of basal respiration, indicative glycolysis and ATP-linked respiration of H1299 (A) and A549 (B) shHSPD1 cells compared to pLKO cells. Bars are average values of biological replicates ± SD. P-values are from unpaired t-test. * < 0.05, **** < 0.0001. Images of tumors from NSG mice injected subcutaneously with H1299 (C) or A549 (F) pLKO or shHSPD1 cells. Graph showing tumor volume of H1299 (D) or A549 (G) shHSPD1 cells compared to pLKO cells. P-values are from two-way ANOVA. Points are average of tumors in (C, F) ± SD. **** < 0.0001. Bar graph showing weight of H1299 (E) and A549 (H) shHSPD1 tumors compared to pLKO tumors. Bars are average of tumors in (C, F) ± SD. P-values are from unpaired t-test. **** < 0.0001