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. 2021 Aug 6;19:232. doi: 10.1186/s12957-021-02339-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — C3G suppressed the expression of TP53I3 in H1299 and A549 cells. A The database of BATMAN, CTD, and DisGeNET showed that C3G was closely associated with six genes (TP53I3, CRYZ, NQO1, SOD1, SOD2, and CBR1). B The expression of TP53I3 in LUAD tissues from TGCA. C Kaplan–Meier curve of the LUAD clinical outcome for TP53I3 from TCGA. D The expression of TP53I3 was detected by qRT-PCR in BEAS-2B, H1299, and A549 cells. E After transfection of si-TP53I3, the expression of TP53I3 in H1299 and A549 cells was detected by qRT-PCR. F After the treatment of C3G (10, 20, and 40 μM), the expression of TP53I3 in H1299 and A549 cells was detected by qRT-PCR. G After the treatment of C3G (10, 20, and 40 μM), the expression of TP53I3 in H1299 and A549 cells was measured by western blot. ^**P < 0.01, vs. BEAS-2B cells group (D); ^**P < 0.01, vs. si-NC group (E); ^**P < 0.01, vs. Control group (F and G)