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C3G inhibited the activation of PI3K/AKT/mTOR pathway in H1299 and A549 cells by downregulating TP53I3. A GSEA showed that the expression of TP53I3 was positively correlated with PI3K/AKT/mTOR pathway. B After the treatment of C3G (40 μM) or si-TP53I3, the expressions of p-PI3K, PI3K, p-AKT, AKT, p-mTOR, and mTOR in H1299 and A549 cells were measured by western blot. **P < 0.01, vs. si-NC group; ##P < 0.01, vs. si-TP53I3 group; &&P < 0.01, vs. C3G + si-NC group
